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NameEmailPhD ProgramResearch InterestPublications
Brunk, Elizabeth
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Bioinformatics & Computational Biology, Chemistry, Pharmacology

RESEARCH INTEREST
Biochemistry, Bioinformatics, Biophysics, Cancer Biology, Computational Biology, Genomics, Pharmacology, Structural Biology, Systems Biology, Translational Medicine

A growing body of work in the biomedical sciences generates and analyzes omics data; our lab’s work contributes to these efforts by focusing on the integration of different omics data types to bring mechanistic insights to the multi-scale nature of cellular processes. The focus of our research is on developing systems genomics approaches to study the impact of genomic variation on genome function. We have used this focus to study genetic and molecular variation in both natural and engineered cellular systems and approach these topics through the lens of computational biology, machine learning and advanced omics data integration. More specifically, we create methods to reveal functional relationships across genomics, transcriptomics, ribosome profiling, proteomics, structural genomics, metabolomics and phenotype variability data. Our integrative omics methods improve understanding of how cells achieve regulation at multiple scales of complexity and link to genetic and molecular variants that influence these processes. Ultimately, the goal of our research is advancing the analysis of high-throughput omics technologies to empower patient care and clinical trial selections. To this end, we are developing integrative methods to improve mutation panels by selecting more informative genetic and molecular biomarkers that match disease relevance.

Giri, Gilbert

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Bioinformatics, Computational Biology, Genetics

Merker, Jason
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Pathobiology & Translational Science

RESEARCH INTEREST
Bioinformatics, Cancer Biology, Genomics, Pharmacology, Translational Medicine

Our laboratory is focused on translating novel molecular biomarkers into clinical oncology practice, with the overarching goal of improving the care and survival of patients with cancer. Our group is highly collaborative and applies genomic, genetic, bioinformatic, informatic, statistical, and molecular approaches. Current projects in the laboratory include:

  1. Correlative genomic testing to support clinical trials
  2. Expanded clinical applications of RNA sequencing
  3. Development and application of cell-free circulating tumor nucleic acid assays
Ramos, Silvia
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Biochemistry & Biophysics

RESEARCH INTEREST
Biochemistry, Bioinformatics, Molecular Biology, Pathology, Translational Medicine

Our research is focused on RNA-binding proteins and their physiopathological roles. An understudied aspect of human disease is gene regulation by modulation of mRNA function. In our research lab we investigate functional connections between the RNA-binding protein Zinc Finger Protein 36 Like-2 (ZFP36L2 or L2) and human diseases. L2 is a member of the Tris-Tetra-Proline or Zinc Finger Protein 36 (TTP/ZFP36) family of RNA-binding proteins that bind Adenine-uridine-Rich Elements (AREs) in the 3’ untranslated regions of target mRNAs. Upon binding, L2 accelerates mRNA target degradation and/or inhibits mRNA translation, ultimately decreasing the protein encoded by the L2-target mRNA.

We have three particular goals:

  • Determine new specific L2-mRNA targets involved in human diseases.
  • Determine the mechanism(s) by which L2 modulates these novel RNA targets.
  • Determine the physiological consequences of L2 ablation in specific cells types using mouse models and CRISPR/Cas9-mediated knockout system.
Alkhawaja, Abdalla

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Bioinformatics, Computational Biology, Genomics

Byun, Jess

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Bioinformatics, Computational Biology, Genomics

Eberhard, Quinn

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Bioinformatics, Computational Biology, Structural Biology

Flores, JP

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Biochemistry, Bioinformatics, Epigenetics, Genetics

Forbes, Kwame

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Bioinformatics, Computational Biology, Genetics

Kent, Leslie

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Bacteriology, Bioinformatics, Pathology