Research Interest: Biophysics
Name | PhD Program | Research Interest | Publications |
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Miao, Yinglong WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Our research is focused on the development of novel theoretical and computational methods and AI techniques, which greatly enhance computer simulations and facilitate simulation analysis, and the application of these methods, making unprecedented contributions to biomolecular modeling and drug discovery. In collaboration with leading experimental groups, we combine complementary simulations and experiments to uncover functional mechanisms and design drugs of important biomolecules, including G-protein-coupled receptors (GPCRs), membrane-embedded proteases, RNA-binding proteins, and RNA. At the interface of computational biology, chemistry, biophysics, bioinformatics and pharmacology, our research aims to address three major topics: (i) development of biomolecular enhanced sampling and AI techniques, (ii) multiscale computational modeling of critical cellular signaling pathways, and (iii) AI-driven drug discovery of medically important proteins and RNA for treatments of neurological disorders, heart failure and cancers. |
Leiderman, Karin WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
I am a mathematical biologist interested in the biochemical and biophysical aspects of blood clotting and emergent behavior in biological fluid-structure interaction problems. I especially love mathematical modeling, where creativity, biological knowledge, and mathematical insight meet. My goal is to use mathematical and computational modeling as a tool to learn something new about a biological system, not just to simply match model output to experimental data. My research paradigm includes an integration of mathematical and experimental approaches, together with statistical analyses and inference, to determine mechanisms underlying complex biological phenomena. This paradigm culminates in the contextualization of my findings to both the mathematical and biological communities. My research program is focused mainly on studying the influence of biochemical and biophysical mechanisms on blood coagulation, clot formation, and bleeding. |
Simmons, Jake |
PHD PROGRAM RESEARCH INTEREST |
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Do, Jamie |
PHD PROGRAM RESEARCH INTEREST |
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Jimenez, Alli |
PHD PROGRAM RESEARCH INTEREST |
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Hughes, Jake |
PHD PROGRAM RESEARCH INTEREST |
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Oguche, Solomon |
PHD PROGRAM RESEARCH INTEREST |
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Arango, Camila |
PHD PROGRAM RESEARCH INTEREST |
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Kratochvil, Huong WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
We take inspiration from Nature to build new proteins that guide our understanding of how natural proteins function: we can distill complex natural proteins into simple model proteins where we have exact control over the physicochemical properties of the entire system. Our group combines protein design strategies with biochemistry, biophysics, and structural biology to 1) test mechanistic hypotheses of membrane protein structure and function, and 2) define novel protein-protein interactions in immunology for engineering protein-based therapeutics. |
Nazockdast, Ehssan WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
We are interested in the physics of soft and squishy materials, especially the organization and mechanics of living cellular materials. We use theory and simulation in close collaboration with experiments to understand the complex structural and mechanical behavior of these systems. These questions and our approach to them are interdisciplinary and intersect several traditional fields, including cell biology, biophysics, fluid dynamics and applied mathematics. |