Research Interest: Gene Therapy
Name | PhD Program | Research Interest | Publications |
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Young, Sam WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
My research is focuses on two general areas: 1) Molecular principles of auditory information processing, and 2) Gene Therapy approaches to treat neurological disorders. In regard to our auditory focus, we seek to understand how the molecular machinery in auditory brainstem synapses enables neuronal computations at some of the fastest speeds in the central nervous system to enable the ability to identify and interpret sound information received by the ears. In regard to our gene therapy approaches, we seek to develop novel viral vector technology to create novel therapeutic strategies to treat neuronal dysfunction and degeneration to improve the quality of life of individuals who suffer from neurological diseases. To address these research areas, I employ a multi-disciplinary strategy that encompasses, molecular biology, virology, viral vectors, biophysics, light microscopy, electron microscopy, electrophysiology, and transgenic mouse models. Keywords: Gene therapy, synaptic transmission, Hearing, viral vectors, biophysics, ion channels, calcium signaling, neurodegeneration, molecular medicine, synaptic plasticity, molecular engineering, nanomedicine |
Hsueh, Ming-Feng WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Dr. Hsueh’s research is at the forefront of translational musculoskeletal and aging biology, utilizing cutting-edge multi-omic technologies to pioneer new therapeutic strategies for regenerating damaged joint tissue, with a particular focus on osteoarthritis (OA). Our lab employs advanced in vitro cell culture and cartilage explant models to delve into the mechanisms driving OA pathogenesis and to evaluate the potential of novel drug therapies. A key area of our research investigates the role of noncoding RNAs in human musculoskeletal tissues. We aim to uncover the intricate signaling pathways and downstream gene networks influenced by these noncoding RNAs. Our ultimate goal is to harness this knowledge to enhance the body’s natural repair mechanisms, providing innovative solutions to combat the progression of OA and restore joint function |
Pires, Sabrina |
PHD PROGRAM RESEARCH INTEREST |
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Martin, Carmen |
PHD PROGRAM RESEARCH INTEREST |
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Law, Karissa |
PHD PROGRAM RESEARCH INTEREST |
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Chung, Kay WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
The Chung lab is engineering immune cells, particularly T cells, to achieve maximum therapeutic efficacy at the right place and timing. We explore the crossroads of synthetic biology, immunology, and cancer biology. Particularly, we are employing protein engineering, next-gen sequencing, CRISPR screening, and bioinformatics to achieve our objectives: (1) Combinatorial recipes of transcription factors for T cell programming. (2) Technologies for temporal regulation and/or rewiring of tumor and immune signal activation (chemokine, nuclear, inhibitor receptors). (3) Synthetic oncolytic virus for engineering tumor-T cell crosstalk. |