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NameEmailPhD ProgramResearch InterestPublications
Berlow, Rebecca
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Biochemistry & Biophysics

RESEARCH INTEREST
Biochemistry, Biophysics, Cancer Biology, Molecular Medicine, Structural Biology

Our lab is interested in the molecular mechanisms of adaptive stress responses. These responses to environmental or metabolic stress are essential for survival but frequently dysregulated in disease. We use an integrated approach combining biophysical, structural, and biochemical methods to investigate the roles of intrinsically disordered proteins and dynamic enzymes that orchestrate these critical stress responses, with the ultimate goal of developing new approaches for modulating the functions of dynamic molecules.

Brunk, Elizabeth
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Bioinformatics & Computational Biology, Chemistry, Pharmacology

RESEARCH INTEREST
Biochemistry, Bioinformatics, Biophysics, Cancer Biology, Computational Biology, Genomics, Pharmacology, Structural Biology, Systems Biology, Translational Medicine

A growing body of work in the biomedical sciences generates and analyzes omics data; our lab’s work contributes to these efforts by focusing on the integration of different omics data types to bring mechanistic insights to the multi-scale nature of cellular processes. The focus of our research is on developing systems genomics approaches to study the impact of genomic variation on genome function. We have used this focus to study genetic and molecular variation in both natural and engineered cellular systems and approach these topics through the lens of computational biology, machine learning and advanced omics data integration. More specifically, we create methods to reveal functional relationships across genomics, transcriptomics, ribosome profiling, proteomics, structural genomics, metabolomics and phenotype variability data. Our integrative omics methods improve understanding of how cells achieve regulation at multiple scales of complexity and link to genetic and molecular variants that influence these processes. Ultimately, the goal of our research is advancing the analysis of high-throughput omics technologies to empower patient care and clinical trial selections. To this end, we are developing integrative methods to improve mutation panels by selecting more informative genetic and molecular biomarkers that match disease relevance.

Ramos, Silvia
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Biochemistry & Biophysics

RESEARCH INTEREST
Biochemistry, Bioinformatics, Molecular Biology, Pathology, Translational Medicine

Our research is focused on RNA-binding proteins and their physiopathological roles. An understudied aspect of human disease is gene regulation by modulation of mRNA function. In our research lab we investigate functional connections between the RNA-binding protein Zinc Finger Protein 36 Like-2 (ZFP36L2 or L2) and human diseases. L2 is a member of the Tris-Tetra-Proline or Zinc Finger Protein 36 (TTP/ZFP36) family of RNA-binding proteins that bind Adenine-uridine-Rich Elements (AREs) in the 3’ untranslated regions of target mRNAs. Upon binding, L2 accelerates mRNA target degradation and/or inhibits mRNA translation, ultimately decreasing the protein encoded by the L2-target mRNA.

We have three particular goals:

  • Determine new specific L2-mRNA targets involved in human diseases.
  • Determine the mechanism(s) by which L2 modulates these novel RNA targets.
  • Determine the physiological consequences of L2 ablation in specific cells types using mouse models and CRISPR/Cas9-mediated knockout system.
Capener, Jacob

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Biochemistry, Biophysics, Pharmacology

Chen, Jingting

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Biochemistry, Cancer Biology, Immunology, Pharmacology

Flores, JP

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Biochemistry, Bioinformatics, Epigenetics, Genetics

Neary, Alex

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Biochemistry, Biophysics, Cell Biology

So, Christina

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Biochemistry, Biophysics, Cell Biology

Hvasta, Matt

EMAIL

PHD PROGRAM

RESEARCH INTEREST
Biochemistry, Biophysics, Computational Biology

Baldwin, Katie
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Cell Biology & Physiology, Neuroscience

RESEARCH INTEREST
Biochemistry, Cell Biology, Developmental Biology, Molecular Biology, Neurobiology

Building a functioning brain requires an elaborate network of interactions between neurons and glia. We use mouse genetics, primary cell culture, quantitative proteomics, molecular biology, and super resolution microscopy to study glial cells during brain development. We are particularly interested in how astrocytes acquire their complex morphology and communicate with neighboring astrocytes, neurons, and oligodendrocytes. Furthermore, we are investigating how glial dysfunction drives the pathogenesis of brain disorders such as autism, schizophrenia, and leukodystrophy.