Liu, Qingyun
EMAIL
PUBLICATIONS |
PHD PROGRAM
Genetics & Molecular Biology RESEARCH INTEREST
Bacteriology, Bioinformatics, Ecology, Evolutionary Biology, Genetics, Genomics, Microscopy/Imaging, Molecular Biology, Molecular Mechanisms of Disease, Pathogenesis & Infection
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Traditionally, basic science has sought to enter the translational pipeline through what can be referred to as “Bottom-Up” science, that is, studies that start with a hypothesis in the lab and aim to develop clinical relevance of the findings. In some cases, notably in conventional antibiotic development, this has worked well – but it assumes one-size fits all solutions that are only as good as our assumptions about the biology of many infectious diseases such as tuberculosis. By contrast, my research focuses on a “Top-Down” approach, leveraging the power of bacterial population genomics to identify bacterial processes important for Mtb success in people and to then employ cutting-edge experimental techniques to mechanistically dissect these processes with the goal of leveraging them using new translational tools.
In my work to date, I have applied this “Top-Down” strategy to define bacterial determinants of treatment outcomes and transmission success, as evident in first-author/corresponding author publications in prestigious journals such as Science, Nature Ecology Evolution, Cell Host Microbe, Science Advances, Genome Biology, PNAS, etc. My work combines expertise in evolutionary biology and bacterial genomics, cutting-edge bacterial genetics and high-throughput experimental phenotyping.
In my own lab, I will use these tools to (1) define the biological mechanisms that enable Mtb to survive antibiotic treatment; (2) identify bacterial determinants of TB transmission success; and (3) elucidate the evolutionary mechanisms underlying the emergence of new bacterial pathogens.
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van Duin, David
WEBSITE
EMAIL
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PHD PROGRAM
Microbiology & Immunology RESEARCH INTEREST
Antibiotics/Antivirals, Bacteriology, Disease, Pathogenesis & Infection, Translational Medicine
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I am a clinical/translational researcher in Infectious Diseases. I am the Director of the Immunocompromised Host Program – which provides ID care to patients with transplants, malignancies, and burns. My primary research interests are antibacterial resistance in gram-negative bacilli, and infections in vulnerable patients. I am the PI for the Carbapenem Resistance Consortium for Klebsiella and other Enterobacteriaceae (CRACKLE) and PI for the Multi-Drug Resistant Organism (MDRO) Network. I am also supported by NIAID to evaluate community origins of carbapenem-resistant Enterobacterales.
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Ott, Isabel
EMAIL
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PHD PROGRAM
RESEARCH INTEREST
Evolutionary Biology, Pathogenesis & Infection, Virology
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“I’m interested in understanding what drives vector-borne virus transition between endemic and epidemic transmission cycles, including virus evolution, ecology, epidemiology, and pathogenesis. I hope to focus on arboviruses endemic to North America, and the ways eco-epidemiological change has shaped disease burdens in these largely understudied viruses.”
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Harrison, Shenice
EMAIL
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PHD PROGRAM
RESEARCH INTEREST
Cell Biology, Immunology, Pathogenesis & Infection
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“My research interests lie in the intersection of pathogenesis and host-pathogen interactions, and microbiology. I aim to explore the molecular basis of infectious diseases and develop novel treatments and vaccines. Within microbiology, I am particularly interested in investigating the genetic mechanisms that regulate microorganism biology and how this knowledge can be applied to advance medical treatments. Additionally, I aim to understand the molecular mechanisms of disease pathogenesis in microorganisms.”
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Robles, Celeste
EMAIL
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PHD PROGRAM
RESEARCH INTEREST
Pathogenesis & Infection, Pathology, Virology
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“Pathogenesis and pathology are the areas of research I find myself most interested in. I’m interested in researching the cellular and molecular mechanisms of disease, especially a disease that disproportionately affects underrepresented populations. I have a broad range of diseases I’d be open to researching!”
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Griffith, Lauren
EMAIL
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PHD PROGRAM
RESEARCH INTEREST
Cancer Biology, Immunology, Pathogenesis & Infection
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“My current research interests are in cancer research, specifically how the microenvironment affects tumor development and progression. I am interested in analyzing how gut microbiota composition can impact disease formation and progression, as well as how genetic factors and mutations can impact it as well.”
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Weight, Abbie
EMAIL
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PHD PROGRAM
RESEARCH INTEREST
Pathogenesis & Infection, Translational Medicine, Virology
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“I am interested in virus-host interactions, viral pathogenesis, and understanding how host immunity controls or contributes to pathogenesis. I am particularly interested in working with arboviruses.”
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Hand, Emily
EMAIL
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PHD PROGRAM
RESEARCH INTEREST
Bacteriology, Pathogenesis & Infection, Translational Medicine
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“I am interested in the intersection of microbial pathogenesis and translational/public health applications. Broadly, this includes infectious diseases, the microbiome, translational/clinical research, and epidemiology.”
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Ogrodniczuk, Marcin
EMAIL
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PHD PROGRAM
RESEARCH INTEREST
Bacteriology, Pathogenesis & Infection, Pathology
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“I’m interested in microbiology and infectious disease research. I am particularly interested in the use of animal models to understand immune system mechanisms.”
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Alam, Ida
EMAIL
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PHD PROGRAM
RESEARCH INTEREST
Immunology, Pathogenesis & Infection, Virology
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“In graduate school, I would like to deepen my knowledge of molecular virology, host-pathogen interaction, immune homeostasis, immune memory generation, and immune response to viral infection and cancer.”
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