Research Interest: Structural Biology
Name | PhD Program | Research Interest | Publications |
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Sode, Koji WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Our strategic research concept is to create novel molecules through biomolecular engineering to develop biosensing technologies dedicated to health care management. Ultimately, we aim to create innovative biodevices to realize closed-loop therapies which can aid in the detection and/or diagnosis of medical conditions and provide medicine/treatment to patients suffering from various diseases (metabolic disorders, neural degenerative diseases, mental disorders, cancer, etc.). The targets for our biomolecular engineering are enzymes, antibodies, binding proteins, receptors/transporters, aptamers, and synthetic molecules. |
Tamir, Tigist WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Systems Metabolism and Signaling Lab Oxidative stress, a byproduct of energy production essential for all living organisms, arises from an imbalance of reactive oxygen, nitrogen, and carbonyl species (ROS/RNS/RCS). These highly reactive molecules present a significant waste management challenge within cells. Through evolution, oxidative stress response (OSR) pathways have emerged as critical guardian of cellular homeostasis, adept at neutralizing potentially harmful reactive molecules. Dysregulation of OSR—whether due to insufficient or excessive capacity to resolve oxidative damage—is a hallmark of numerous human diseases. For example, cancer cells co-opt OSR pathways by rewiring signaling and metabolism which leads to the development of resistance to chemotherapy. The Systems Metabolism and Signaling Lab (i.e. Tamir Lab) seeks to unravel the biochemical intricacies of how cells defend against oxidative stress by investigating the cell signaling-mediated regulation of metabolism. We aim to address fundamental questions about the biochemistry of OSR regulation, including:
To tackle these questions, we employ a multidisciplinary approach that integrates biochemistry, proteomics, metabolomics, molecular biology, and systems biology. Our work focuses on dissecting the regulatory networks governing OSR and identifying targetable pathways implicated in obesity and cancer. As a member of the Lineberger Comprehensive Cancer Center, Department of Nutrition, and Computational Medicine Program, we bridge molecular insights with systems-level understanding as we strive to illuminate novel and effective strategies for therapeutic interventions. The Systems Metabolism and Signaling Lab is committed to fostering a collaborative, creative, and diverse group that is invested in mutual growth. |
Jenson, Justin WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Our lab studies molecular interactions between bacteria and the viruses that infect them, called phage. For billions of years, phage and bacteria have been locked in a ‘molecular arms race’. To survive, bacteria have evolved many immune systems to protect against infection and, in response, phage have counter-adapted to evade these defenses. Our lab is interested in 1) understanding how these systems work biochemically and structurally and 2) discovering new factors involved in this ‘molecular arms race’. We are particularly interested in systems that share homology with human immune factors. |
Taggart, Lizzy |
PHD PROGRAM RESEARCH INTEREST |
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Paulakonis, Ethan |
PHD PROGRAM RESEARCH INTEREST |
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Mileur, Trevor |
PHD PROGRAM RESEARCH INTEREST |
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Liebow, Elise |
PHD PROGRAM RESEARCH INTEREST |
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Harrison, Jonathan |
PHD PROGRAM RESEARCH INTEREST |
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Eidman, Allie |
PHD PROGRAM RESEARCH INTEREST |
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Guardia, Charly WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
The human placenta is the first organ to develop after fertilization and is the least studied! We hope to change this by using a multidisciplinary approach. From iPSC-derived trophoblasts in culture to mouse models and human placenta tissue, the Placental Cell Biology Group at NIEHS answers fundamental questions about placenta cell and developmental biology. Our lab uses a range of microscopy (cryo-EM, fluorescence), recombinant protein production, and -omics techniques. The goal of our research is to understand how autophagy controls placenta development, differentiation, and function. |