Research Interest: Molecular Biology
| Name | PhD Program | Research Interest | Publications |
|---|---|---|
| Graves, Lee M. WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Our lab is studying the role of mitogen and stress-activated protein kinases to regulate key aspects of cell metabolism. We are also studying signalling by tyrosine kinases in response to toxicological agents or cell stress. |
| Gordon-Larsen, Penny WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Gordon-Larsen’s work integrates biology, behavior, and environment to understand, prevent and treat obesity, cardiovascular and cardiometabolic diseases. She works with biomarker, microbiome, metabolome, genetic, weight, diet, and environment data using multilevel modeling and pathway-based analyses. She works with several longitudinal cohorts that span more than 30 years. Most of her work uses data from the US and China. Her research teams include a wide variety of scientists working in areas such as genetics, medicine, bioinformatics, biostatistics, microbiology, nutrition, and epidemiology. |
| Goldstein, Bob WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
We address fundamental issues in cell and developmental biology, issues such as how cells move to specific positions, how the orientations of cell divisions are determined, how the mitotic spindle is positioned in cells, and how cells respond to cell signaling – for example Wnt signaling, which is important in development and in cancer biology. We are committed to applying whatever methods are required to answer important questions. As a result, we use diverse methods, including methods of cell biology, developmental biology, forward and reverse genetics including RNAi, biochemistry, biophysics, mathematical and computational modeling and simulations, molecular biology, and live microscopy of cells and of the dynamic components of the cytoskeleton – microfilaments, microtubules, and motor proteins. Most experiments in the lab use C. elegans embryos, and we have also used Drosophila and Xenopus recently. C. elegans is valuable as a model system because of the possibility of combining the diverse techniques above to answer a wide array of interesting questions. We also have a long-term project to develop a new model system for studying how biological materials can survive extremes, using little-studied organisms called tardigrades. Rotating graduate students learn to master existing techniques, and students who join the lab typically grow their rotation projects into larger, long term projects, and/or develop creative, new projects. |
| Furey, Terry WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
The Furey Lab is interested in understanding gene regulation processes in specific cell types, especially with respect to complex phenotypes, and the effect of genetic and environmental variation on gene regulation. We have explored these computationally by concentrating on the analysis of genome-wide open chromatin data generated from high-throughput sequencing experiments; and the development of statistical methods and computational tools to investigate underlying genetic and biological mechanisms of complex phenotypes. Our current projects include determining the molecular effects of exposure to ozone on chromatin, gene regulation, and gene expression in alveolar (lung) macrophages of genetically diverse mouse strains. We are also exploring genetics, chromatin, transcriptional, and microbial changes in inflammatory bowel diseases to identify biomarkers of disease onset, severity, and progression. |
| Errede, Beverly WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Yeast molecular genetics; MAP-Kinease activation pathways; regulation of cell differentiation. |
| Emanuele, Michael WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Our lab applies cutting edge genetic and proteomic technologies to unravel dynamic signaling networks involved in cell proliferation, genome stability and cancer. These powerful technologies are used to systematically interrogate the ubiquitin proteasome system (UPS), and allow us to gain a systems level understanding of the cell at unparalleled depth. We are focused on UPS signaling in cell cycle progression and genome stability, since these pathways are universally perturbed in cancer. |
| Duronio, Bob WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
My lab studies how cell proliferation is controlled during animal development, with a focus on the genetic and epigenetic mechanisms that regulate DNA replication and gene expression throughout the cell cycle. Many of the genes and signaling pathways that we study are frequently mutated in human cancers. Our current research efforts are divided into three areas: 1) Plasticity of cell cycle control during development 2) Histone mRNA biosynthesis and nuclear body function 3) Epigenetic control of genome replication and function. |
| de Silva, Aravinda WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
We study Borrelia burgdorferi (the agent of Lyme disease) as a model for understanding arthropod vector-borne disease transmission. We also study the epidemiology and pathogenesis of dengue viruses associated with hemorrhagic disease. |
| Davis, Ian WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
With a particular interest in pediatric solid tumors, our lab aims to develop a mechanistic understanding of the role of aberrant or dysregulated transcription factors in oncogenesis. |
| Cyr, Douglas M. WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
The Cyr laboratory studies cellular mechanisms for cystic fibrosis and prion disease. We seek to determine how protein misfolding leads to the lung pathology associated with Cystic Fibrosis and the neurodegeneration associated with prion disease. |