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NameEmailPhD ProgramResearch InterestPublications
Legant, Wesley R.
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Pharmacology

RESEARCH INTEREST
Biomaterials, Cancer Biology, Cell Biology, Cell Signaling, Computational Biology

Life is animate and three-dimensional.  Our lab develops tools to better understand living specimens at single molecule, cellular, and tissue level length scales.  Our current efforts comprise three synergistic research areas: 1) development and application of novel fluorescent imaging modalities including: super resolution, light sheet, and adaptive optical microscopy 2) investigation of how mechanical forces and cytoskeletal dynamics drive cancer cell migration through complex three-dimensional environments, and 3) generation of microfabricated platforms to precisely control the cellular microenvironment for tissue engineering and drug screening.

Ikonomidis, John S.
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Biology, Cell Biology & Physiology

RESEARCH INTEREST
Biochemistry, Cardiovascular Biology, Cell Biology, Cell Signaling, Translational Medicine

My research focus pertains to vascular remodeling as it relates to the pathogenesis and progression of thoracic aortic aneurysms. Using murine and porcine models, as well as human aneurysm tissue samples, we study proteinase and signaling biology with a view towards defining novel modalities targets for diagnosis, tracking, risk stratification and non-surgical treatment of this devastating disease.

Williams, Carmen J.
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Toxicology

RESEARCH INTEREST
Cell Biology, Cell Signaling, Developmental Biology, Toxicology, Translational Medicine

Reproductive biology of early mammalian embryogenesis including gametogenesis, fertilization, and preimplantation embryo development. Effects of environmental disrupting chemicals on female reproductive tract development and function, with a focus on epigenetic alterations.

Liu, Zhi
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Microbiology & Immunology

RESEARCH INTEREST
Biochemistry, Cell Biology, Cell Signaling, Immunology, Pathogenesis & Infection

Biochemistry, cell biology, and immunology of skin, immunopathogenesis of autoimmune and inflammatory skin blistering diseases.

Liu, Rihe
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Pharmaceutical Sciences

RESEARCH INTEREST
Biochemistry, Biophysics, Cell Signaling, Chemical Biology, Nanomedicine

The research interests of the Liu Lab are in functional proteomics and biopharmaceuticals. Currently we are working on the following projects:  (1). Using systems biology approaches to decipher the signaling pathways mediated by disease-related proteases such as caspases and granzymes and by post-translationally modified histones. We address these problems by performing functional protein selections using mRNA-displayed proteome libraries from human, mouse, Drosophila, and C. elegans. (2). Developing novel protein therapeutics and nucleic acid therapeutics that can be used in tumor diagnosis, treatment, and nanomedicine. We use various amplification-based molecular evolution approaches such as mRNA-display and in vivo SELEX to develop novel single domain antibody mimics on the basis of very stable protein domains or to generate aptamers on the basis of nuclease-resistant nucleic acids, that bind to important biomarkers on the surface of cancer cells. We further conjugate these biomarker-binding affinity reagents to small molecule drugs or nanoparticles for targeted delivery of therapeutic agents. (3). Identifying the protein targets of drugs or drug candidates whose action mechanisms are unknown. We combine molecular proteomic and chemical biology approaches to identify the protein targets of drugs whose target-binding affinities are modest.

Liu, Pengda
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Biochemistry & Biophysics

RESEARCH INTEREST
Biochemistry, Cancer Biology, Cell Biology, Cell Signaling, Drug Discovery

If you are interested in developing new biochemical/molecular techniques/tools to advance our understanding of biology, and if you are interested in signal transduction pathway analyses and identification of cancer biomarkers, our research group may help you to achieve your goals, as we have the same dreams. We are especially interested in deciphering the molecular mechanisms underlying aberrant signaling events that contribute to tumorigenesis, mediated through protein modifications and protein-protein interactions. Understanding these events may lead to identification of novel drug targets and provide new treatment strategies to combat human cancer.

Liu, Jiandong
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Cell Biology & Physiology, Pathobiology & Translational Science

RESEARCH INTEREST
Cardiovascular Biology, Cell Biology, Cell Signaling, Developmental Biology, Genetics

Congenital heart diseases are one of the most common birth defects in humans, and these arise from developmental defects during embryogenesis.  Many of these diseases have a genetic component, but they might also be affected by environmental factors such as mechanical forces. The Liu Lab combines genetics, molecular and cell biology to study cardiac development and function, focusing on the molecular mechanisms that link mechanical forces and genetic factors to the morphogenesis of the heart.  Our studies using zebrafish as a model system serve as the basic foundation to address the key questions in cardiac development and function, and could provide novel therapeutic interventions for cardiac diseases.

Tong, Haiyan
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Toxicology

RESEARCH INTEREST
Cardiovascular Biology, Cell Signaling, Physiology, Toxicology, Translational Medicine

Research in my laboratory focuses on the cardiovascular effects of air pollution and other environmental pollutants in human, animal, and in vitro models, as well as the dietary interventional strategies to mitigate the adverse health effects of air pollution exposure. We are currently conducting two clinical studies to investigate the cardiopulmonary effects of air pollution exposure, and to determine whether dietary omega-3 fatty acids can mitigate the air pollution-induced health effects in human volunteers. These studies provide good training opportunities for students who are interested in training in clinical and translational toxicology research.

Martinez, Jennifer
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Microbiology & Immunology

RESEARCH INTEREST
Cell Biology, Cell Signaling, Immunology, Molecular Biology, Pathogenesis & Infection, Virology

The focus of the work in the Martinez lab is to examine the non-canonical roles for the autophagy machinery during inflammation. Our recent work about LC3-associated phagocytosis (LAP) higlights the importance of this non-canonical autophagic process in maintaining tolerance and preventing unwanted autoinflammatory pathologies.

Hahn, Klaus
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Bioinformatics & Computational Biology, Cell Biology & Physiology, Neuroscience, Pharmacology

RESEARCH INTEREST
Biochemistry, Biophysics, Cell Biology, Cell Signaling, Chemical Biology, Computational Biology, Systems Biology

Dynamic control of signaling networks in living cells; Rho family and MAPK networks in motility and network plasticity; new tools to study protein activity in living cells (i.e., biosensors, protein photomanipulation, microscopy). Member of the Molecular & Cellular Biophysics Training Program and the Medicinal Chemistry Program.