Research Interest: Biochemistry
| Name | PhD Program | Research Interest | Publications |
|---|---|---|
| Hursting, Stephen D WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Dr. Hursting’s lab focuses on the molecular and metabolic mechanisms underlying nutrition and cancer associations, particularly the impact of obesity and energy balance modulation (eg, calorie restriction, exercise) on cancer development or responses to chemotherapy. Primarily using genetically engineered mouse models of pancreatic, colon and breast cancer, Dr. Hursting has identified the IGF-1/Akt/mTOR and NF-kB signaling pathways as key targets for breaking the obesity- cancer link. He has also established in several preclinical models of pancreatic and breast cancer that obesity impacts the response to various forms of chemotherapy. In addition, the Hursting lab is involved in several translational research collaborations linking mouse model studies with clinical trials, and his group has expertise in measuring metabolic hormones, growth factors, inflammatory cytokines and chemokines in serum and tissue from rodents and humans. |
| Krupenko, Sergey WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Dr. Krupenko’s research is focused on the role of folate metabolism in cellular homeostasis and cancer disease. He is especially interested in the function of a major folate enzyme and a putative tumor suppressor ALDH1L1 as metabolic regulator and a guardian of non-malignant phenotype. At present he studies function of this enzyme and related proteins using mouse knockout models. Recently his research team has also demonstrated that dietary folate regulates cancer metastasis. He now pursues studies of specific signaling pathways involved in metastatic response to dietary folate status. |
| Snider, Natasha WEBSITE PUBLICATIONS |
PHD PROGRAM RESEARCH INTEREST |
Our lab has two areas of interest: the molecular basis of liver diseases and the biochemical mechanisms of disorders linked to intermediate filament gene mutations. We use biochemical, cell-based and in vivo approaches to identify potential disease targets and to understand their function and regulation. The major goal of our work is to promote the discovery of pharmacological agents that can slow or halt the progression of these diseases. |