Hematology | Research Interests

Name	Email	PhD Program	Research Interest	Publications
Sparkenbaugh, Erica WEBSITE EMAIL PUBLICATIONS	PHD PROGRAM Pathobiology & Translational Science RESEARCH INTEREST Cell Signaling, Genetic Basis of Disease, Hematology, Immunology, Molecular Mechanisms of Disease	The broad goal in my laboratory is to investigate crosstalk between coagulation and inflammation in animal models of disease. My primary interest is sickle cell disease, a blood disorder caused by a hemoglobin mutation that results in sickling of red blood cells. The primary complications of sickle cell disease are anemia and vaso-occlusive crisis (VOC), as well as chronic inflammation and coagulation activation. VOC is caused by the formation of multicellular aggregates between neutrophils, platelets, sickle red blood cells and the endothelium that is due, in part, to thrombin-dependent activation of protease activated receptor 1 (PAR-1). We are currently investigating how biased agonism of PAR1 with activated protein C (APC) can beneficially influence vaso-occlusive crisis and other pathologies in sickle cell disease. We use a variety of tools, such as transgenic mice, clinically relevant pharmacologic inhibitors, and molecular and cellular biology techniques to study the role of coagulation proteases and protease activated receptors in health and disease.
Leiderman, Karin WEBSITE EMAIL PUBLICATIONS	PHD PROGRAM Biochemistry & Biophysics, Bioinformatics & Computational Biology RESEARCH INTEREST Biophysics, Cardiovascular Biology, Cell Signaling, Computational Biology, Enzymology, Hematology, Pharmacology, Quantitative Biology, Systems Biology	I am a mathematical biologist interested in the biochemical and biophysical aspects of blood clotting and emergent behavior in biological fluid-structure interaction problems. I especially love mathematical modeling, where creativity, biological knowledge, and mathematical insight meet. My goal is to use mathematical and computational modeling as a tool to learn something new about a biological system, not just to simply match model output to experimental data. My research paradigm includes an integration of mathematical and experimental approaches, together with statistical analyses and inference, to determine mechanisms underlying complex biological phenomena. This paradigm culminates in the contextualization of my findings to both the mathematical and biological communities. My research program is focused mainly on studying the influence of biochemical and biophysical mechanisms on blood coagulation, clot formation, and bleeding.

Name

PhD Program

Research Interest

Publications

Sparkenbaugh, Erica
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Pathobiology & Translational Science

RESEARCH INTEREST
Cell Signaling, Genetic Basis of Disease, Hematology, Immunology, Molecular Mechanisms of Disease

The broad goal in my laboratory is to investigate crosstalk between coagulation and inflammation in animal models of disease. My primary interest is sickle cell disease, a blood disorder caused by a hemoglobin mutation that results in sickling of red blood cells. The primary complications of sickle cell disease are anemia and vaso-occlusive crisis (VOC), as well as chronic inflammation and coagulation activation. VOC is caused by the formation of multicellular aggregates between neutrophils, platelets, sickle red blood cells and the endothelium that is due, in part, to thrombin-dependent activation of protease activated receptor 1 (PAR-1). We are currently investigating how biased agonism of PAR1 with activated protein C (APC) can beneficially influence vaso-occlusive crisis and other pathologies in sickle cell disease. We use a variety of tools, such as transgenic mice, clinically relevant pharmacologic inhibitors, and molecular and cellular biology techniques to study the role of coagulation proteases and protease activated receptors in health and disease.

Leiderman, Karin
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Biochemistry & Biophysics, Bioinformatics & Computational Biology

RESEARCH INTEREST
Biophysics, Cardiovascular Biology, Cell Signaling, Computational Biology, Enzymology, Hematology, Pharmacology, Quantitative Biology, Systems Biology

I am a mathematical biologist interested in the biochemical and biophysical aspects of blood clotting and emergent behavior in biological fluid-structure interaction problems. I especially love mathematical modeling, where creativity, biological knowledge, and mathematical insight meet. My goal is to use mathematical and computational modeling as a tool to learn something new about a biological system, not just to simply match model output to experimental data. My research paradigm includes an integration of mathematical and experimental approaches, together with statistical analyses and inference, to determine mechanisms underlying complex biological phenomena. This paradigm culminates in the contextualization of my findings to both the mathematical and biological communities. My research program is focused mainly on studying the influence of biochemical and biophysical mechanisms on blood coagulation, clot formation, and bleeding.

Research Interest: Hematology