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NameEmailPhD ProgramResearch InterestPublications
Madden, Michael C.
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Toxicology

RESEARCH INTEREST
Physiology, Toxicology, Translational Medicine

Exposure to ambient air particulate matter  has been associated with increased human deaths and cardiopulmonary morbidity, such as lung infections and increased asthma symptoms.  I am investigating some types of PM and associated gases  that may be associated with those health effects so  to better regulate or manage the sources of the airborne particles which are identified as playing a role in the adverse health outcomes. I am currently focusing on the effects of diesel exhaust using a variety of approaches ranging from exposing cultured human lung and vascular cells to the exhaust, to studying responses of humans exposed out in traffic.  I am currently designing and implementing testing strategies to assess the toxicity of the future types of vehicular emissions. Additionally some of my research effort attempts to identify what populations are more sensitive to the effects of air pollutants, and the genetic, diet, and environmental reasons behind the increased sensitivity.

Nylander-French, Leena
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Toxicology

RESEARCH INTEREST
Computational Biology, Genetics, Toxicology

My research focuses on understanding the relationship between dermal and inhalation exposure and the effect of individual genetic differences on the function of enzymes that detoxify hazardous agents and that affect the development of disease. My research group has pioneered approaches to quantitatively measure skin and inhalation exposures to toxicants; additionally, my group has developed sophisticated exposure modeling tools using mathematical and statistical principles in an effort to standardize and improve exposure and risk assessment.

Peden, David B.
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Microbiology & Immunology, Toxicology

RESEARCH INTEREST
Toxicology

Translational and clinical research in environmental lung disease.

Randell, Scott
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Cell Biology & Physiology, Toxicology

RESEARCH INTEREST
Cancer Biology, Cell Biology, Drug Discovery, Immunology, Molecular Medicine, Pathogenesis & Infection, Physiology, Stem Cells, Toxicology, Translational Medicine

My laboratory research is focused on basic cell biology questions as they apply to clinical lung disease problems. Our main work recently has been contributing to the Cystic Fibrosis (CF) Foundtation Stem Cell Consortium, with a focus on developing cell and gene editing therapies for CF. I contribute to UNC team science efforts on cystic fibrosis, aerodigestive cancers, emerging infectious diseases and inhalation toxicology hazards. I direct a highly respected tissue procurement and cell culture Core providing primary human lung cells and other resources locally, nationally and internationally. I co-direct the Respiratory Block in the UNC Translational Educational Curriculum for medical students and also teach in several graduate level courses.

Redinbo, Matt
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Biochemistry & Biophysics, Bioinformatics & Computational Biology, Chemistry, Microbiology & Immunology, Oral & Craniofacial Biomedicine, Pathobiology & Translational Science, Pharmaceutical Sciences, Pharmacology

RESEARCH INTEREST
Bacteriology, Biochemistry, Bioinformatics, Biophysics, Cancer Biology, Chemical Biology, Computational Biology, Drug Delivery, Drug Discovery, Metabolism, Microbiology, Molecular Biology, Molecular Medicine, Pharmacology, Plant Biology, Structural Biology, Systems Biology, Toxicology

We are interested in unraveling the molecular basis for human disease and discover new treatments focused on human and microbial targets. Our work extends from atomic-level studies using structural biology, through chemical biology efforts to identify new drugs, and into cellular, animal and clinical investigations. While we are currently focused on the gut microbiome, past work has examined how drugs are detected and degraded in humans, proteins designed to protect soldiers from chemical weapons, how antibiotic resistance spreads, and novel approaches to treat bacterial infections. The Redinbo Laboratory actively works to increase equity and inclusion in our lab, in science, and in the world. Our lab is centered around collaboration, open communication, and trust. We welcome and support anyone regardless of race, disability, gender identification, sexual orientation, age, financial background, or religion. We aim to: 1) Provide an inclusive, equitable, and encouraging work environment 2) Actively broaden representation in STEM to correct historical opportunity imbalances 3) Respect and support each individual’s needs, decisions, and career goals 4) Celebrate our differences and use them to discover new ways of thinking and to better our science and our community

Samet, James M.
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Toxicology

RESEARCH INTEREST
Immunology, Toxicology

Our laboratory is focused on the cellular and molecular mechanisms that control  inflammatory and adaptive responses induced by inhalation of ambient air pollutants. Projects focus on early events that result in the disregulation of signaling processes that regulate gene expression, specifically oxidative effects that disrupt signaling quiescence in human lung cells. Approaches include live-cell imaging of human lung cells exposed in vitro and ex-vivo and characterization of oxidative protein modifications.

Styblo, Miroslav
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Nutrition, Toxicology

RESEARCH INTEREST
Physiology, Toxicology

Dr. Styblo is a biochemist with background in nutritional biochemistry and biochemical toxicology. His research focuses on topics that require expertise in both nutrition and toxicology and typically involve a translational or interdisciplinary approach. His current research projects examine mechanisms and etiology of diseases associated with exposures to environmental toxins with main focus on cancer and diabetes associated with exposure to arsenic (a common drinking water contaminant), and on the role of diet or specific nutrients in prevention of these diseases.

Tropsha, Alexander
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Bioinformatics & Computational Biology, Neuroscience, Pharmaceutical Sciences, Toxicology

RESEARCH INTEREST
Bioinformatics, Computational Biology, Molecular Medicine, Structural Biology, Toxicology

The major area of our research is Biomolecular Informatics, which implies understanding relationships between molecular structures (organic or macromolecular) and their properties (activity or function). We are interested in building validated and predictive quantitative models that relate molecular structure and its biological function using statistical and machine learning approaches. We exploit these models to make verifiable predictions about putative function of untested molecules.

Vaziri, Cyrus
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Genetics & Molecular Biology, Pathobiology & Translational Science, Toxicology

RESEARCH INTEREST
Cancer Biology, Cell Biology, Cell Signaling, Molecular Biology, Toxicology

Our broad long-term goal is to understand how mammalian cells maintain ordered control of DNA replication during normal passage through an unperturbed cell cycle, and in response to genotoxins (DNA-damaging agents).  DNA synthesis is a fundamental process for normal growth and development and accurate replication of DNA is crucial for maintenance of genomic stability.  Many cancers display defects in regulation of DNA synthesis and it is important to understand the molecular basis for aberrant DNA replication in tumors.  Moreover, since many chemotherapies specifically target cells in S-phase, a more detailed understanding of DNA replication could allow the rational design of novel cancer therapeutics.  Our lab focuses on three main aspects of DNA replication control:  (1) The S-phase checkpoint, (2) Trans-Lesion Synthesis (TLS) and (3) Re-replication.

Watkins, Paul
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Toxicology

RESEARCH INTEREST
Physiology, Toxicology

Mechanistic toxicology, hepato-toxicology, research translation, biomarkers