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NameEmailPhD ProgramResearch InterestPublications
Kakoki, Masao
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Pathobiology & Translational Science

RESEARCH INTEREST
Genetics, Pathology

My research aims at prevention and treatment of cardiovascular diseases and focuses on the identification of genes that confer susceptibility or resistance to the diseases with the use of genetically engineered mice. In collaboration with Dr.Oliver Smithies, I very recently developed a new method for altering gene expression by modifying 3’ untranslated regions in mice which enables fine-tuned modification of gene expression. I am now analyzing the phenotypes of several mouse models generated with this method.

Kesimer, Mehmet
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Pathobiology & Translational Science

RESEARCH INTEREST
Biochemistry, Cell Biology, Molecular Biology, Pathology, Translational Medicine

One of the main focuses of my work is the characterization of the large mucin gene products (Mr 2-3 million) and the complexes they make (Mr 10-100 million) essential for the formation of the mucus gels vital for epithelial protection and function. My current work is focused around the human lung, where there are many hypersecretory human diseases, including asthma, cystic fibrosis, and chronic bronchitis, in which these glycoconjugates are centrally implicated. Basic understanding of the qualitative and quantitative changes of mucin macromolecules in lung health and diseases is our main task.

Mack, Christopher P.
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Cell Biology & Physiology, Pathobiology & Translational Science

RESEARCH INTEREST
Cardiovascular Biology, Cell Signaling, Developmental Biology, Molecular Biology, Pathology

My research goals are to identify the mechanisms by which environmental factors regulate smooth muscle cell phenotype and to define the transcriptional pathways that regulate SMC-specific gene expression.

Mackman, Nigel
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Pathobiology & Translational Science

RESEARCH INTEREST
Cancer Biology, Cardiovascular Biology, Cell Signaling, Pathology, Translational Medicine

The major focus of Mackman lab is the procoagulant protein tissue factor. This is the primary cellular initiator of blood coagulation. We study its role in hemostasis, thrombosis, inflammation, ischemia-reperfusion injury and tumor growth.  We have generated a number of mouse models expressing different levels of both mouse and human tissue factor. These mice have been used to provide new insights into the role of tissue factor in hemostasis and thrombosis. In 2007, we developed a new assay to measure levels of microparticle tissue factor in plasma. We found that elevated levels of microparticle tissue factor are associated with venous thromboembolism in cancer patients.

Nichols, Timothy C.
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Pathobiology & Translational Science

RESEARCH INTEREST
Molecular Biology, Pathology

My research interests include the role of von Willebrand factor in thrombosis and atherosclerosis. Our current lab work focuses on the molecular biology of porcine von Willebrand factor.

Sartor, R. Balfour
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Microbiology & Immunology

RESEARCH INTEREST
Bacteriology, Genetics, Immunology, Pathogenesis & Infection, Pathology

Our long term goals are to better define mechanisms of chronic intestinal inflammation and to identify areas for therapeutic intervention. Research in our laboratories is in the following four general areas: 1) Induction and perpetuation of chronic intestinal and extraintestinal inflammation by resident intestinal bacteria and their cell wall polymers, 2) Mechanisms of genetically determined host susceptibility to bacterial product,. 3) Regulation of immunosuppressive molecules in intestinal epithelial cells and 4) Performing clinical trials of novel therapeutic agents in inflammatory bowel disease patients.

Serody, Jonathan
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Microbiology & Immunology

RESEARCH INTEREST
Cancer Biology, Immunology, Pathology, Physiology

The Serody laboratory focuses on tumor and transplant immunology studies using both animal models and translational work with clinical samples. We have performed pioneering work in both of these areas. Our laboratory was the first to describe a role for migratory proteins in the biology of acute GVHD. We were the first group to use eGFP transgenic mice generated in part by our group to track the migration of donor cells after transplant. This work showed a critical role for lymphoid tissue in the activation of donor T cells. Most recently we have been the first group to demonstrate the absence of ILC2 cells in the GI tract after all types of transplant and we have generated novel studies into the ILC2 niche in the bone marrow. For our tumor work we were one of the first groups to use genomic evaluations of the tumor microenvironment to characterize the immune response in cancer models. We were the first group to demonstrate how to enhance checkpoint inhibitor therapy in triple negative breast cancer models and have been one of the leading groups in performing genomic evaluations using TCGA data. Finally, we are one of the leading groups in the world characterizing the role of B cells in the anti-tumor immune response.

Taylor, Joan M.
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Cell Biology & Physiology, Pathobiology & Translational Science

RESEARCH INTEREST
Cardiovascular Biology, Cell Signaling, Developmental Biology, Genetics, Pathology

The goal of our research is to identify signaling mechanisms that contribute to normal and pathophysiological cell growth in the cardiovascular system.  We study cardiac and vascular development as well as heart failure and atherosclerosis.

Tisch, Roland
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Microbiology & Immunology

RESEARCH INTEREST
Cell Signaling, Immunology, Pathology, Translational Medicine

Projects involve the study of cellular and molecular events involved in autoimmunity, and development and application of genetic vaccines to prevent and treat autoimmunity and cancer.

Wolberg, Alisa
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Pathobiology & Translational Science

RESEARCH INTEREST
Biochemistry, Bioinformatics, Cardiovascular Biology, Microscopy, Molecular Medicine, Pathogenesis & Infection, Pathology, Translational Medicine

We investigate mechanisms in blood coagulation and diseases that intersect with abnormal blood biomarkers and function, including cardiovascular disease (heart attack, stroke, deep vein thrombosis, pulmonary embolism), bleeding (hemophilia), inflammation, obesity, and cancer. We also investigate established drugs and new drugs in preclinical development to understand their role in reducing and preventing disease. Our studies use interdisciplinary techniques, including in vitro, ex vivo, and in vivo mouse models and samples from humans in translational studies that span clinic to bench. Our lab emphasizes a culture of diversity, responsibility, independence and collaboration, and shared excitement for scientific discovery. We are located in the UNC Blood Research Center in the newly-renovated Mary Ellen Jones building.