Developmental Disorders | Research Interests

Name	Email	PhD Program	Research Interest	Publications
Edwards, Whitney EMAIL PUBLICATIONS	PHD PROGRAM Cell Biology & Physiology RESEARCH INTEREST Cardiovascular Biology, Cardiovascular Disease, Cell Biology, Cell Signaling, Developmental Biology, Developmental Disorders, Disease, Genetic Basis of Disease, Metabolism, Molecular Biology, Molecular Mechanisms of Disease	Our lab aims to identify the fundamental molecular mechanisms underlying heart development and congenital heart disease. Our multifaceted approach includes primary cardiac cell culture, genetic mouse models, biochemical/molecular studies, and transcriptomics. Additionally, we employ proteomics-based methods to investigate 1) protein expression dynamics, 2) protein interaction networks, and 3) post-translational modifications (PTMs) in heart development. Current research projects focus on investigating the function of two essential PTMs in cardiogenesis: protein prenylation and palmitoylation.
Guardia, Charly WEBSITE EMAIL PUBLICATIONS	PHD PROGRAM Cell Biology & Physiology RESEARCH INTEREST Biochemistry, Cell Biology, Developmental Biology, Developmental Disorders, Disease, Metabolism, Microscopy/Imaging, Molecular Mechanisms of Disease, Physiology, Structural Biology	The human placenta is the first organ to develop after fertilization and is the least studied! We hope to change this by using a multidisciplinary approach. From iPSC-derived trophoblasts in culture to mouse models and human placenta tissue, the Placental Cell Biology Group at NIEHS answers fundamental questions about placenta cell and developmental biology. Our lab uses a range of microscopy (cryo-EM, fluorescence), recombinant protein production, and -omics techniques. The goal of our research is to understand how autophagy controls placenta development, differentiation, and function.

Name

PhD Program

Research Interest

Publications

Edwards, Whitney

EMAIL
PUBLICATIONS

RESEARCH INTEREST
Cardiovascular Biology, Cardiovascular Disease, Cell Biology, Cell Signaling, Developmental Biology, Developmental Disorders, Disease, Genetic Basis of Disease, Metabolism, Molecular Biology, Molecular Mechanisms of Disease

Our lab aims to identify the fundamental molecular mechanisms underlying heart development and congenital heart disease. Our multifaceted approach includes primary cardiac cell culture, genetic mouse models, biochemical/molecular studies, and transcriptomics. Additionally, we employ proteomics-based methods to investigate 1) protein expression dynamics, 2) protein interaction networks, and 3) post-translational modifications (PTMs) in heart development. Current research projects focus on investigating the function of two essential PTMs in cardiogenesis: protein prenylation and palmitoylation.

Guardia, Charly
WEBSITE
EMAIL
PUBLICATIONS

PHD PROGRAM
Cell Biology & Physiology

RESEARCH INTEREST
Biochemistry, Cell Biology, Developmental Biology, Developmental Disorders, Disease, Metabolism, Microscopy/Imaging, Molecular Mechanisms of Disease, Physiology, Structural Biology

The human placenta is the first organ to develop after fertilization and is the least studied! We hope to change this by using a multidisciplinary approach. From iPSC-derived trophoblasts in culture to mouse models and human placenta tissue, the Placental Cell Biology Group at NIEHS answers fundamental questions about placenta cell and developmental biology. Our lab uses a range of microscopy (cryo-EM, fluorescence), recombinant protein production, and -omics techniques. The goal of our research is to understand how autophagy controls placenta development, differentiation, and function.

Research Interest: Developmental Disorders