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The Yan lab works at the interface of material science, photonics, and biology. We synthesize metal, metal oxide and upconversion nanoparticles for biophotonics and biomedicine applications. We use holographic optical tweezers and atomic force microscope (AFM) to trap and manipulate single nanoparticles, and use them as probes to study nano-bio interactions, including biosensing, bionanomechanics and cell biology. We conduct these studies with a customized multi-modal correlative optical system that combines the nanomanipulation module with advanced optical microscopy and spectroscopy techniques.