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Our research focuses on understanding the biology and pathogenic mechanisms of mycobacterial pathogens, including Mycobacterium tuberculosis, the bacterium responsible for tuberculosis (TB) disease. TB remains a significant world health problem that is responsible for 1.5 million deaths annually and drug resistant TB is an increasing problem.  We additionally study nontuberculous mycobacteria (NTM), which are emerging pathogens responsible for chronic pulmonary infections in individuals with underlying lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease. We also investigate novel strategies to treat mycobacterial infections that include anti-mycobacterial drugs delivered as aerosols and bacteriophage therapy.