Toxicology

Program Overview

The Curriculum in Toxicology Ph.D. program is dedicated to the development of future scientists who are knowledgeable in the basic principles of toxicology and environmental health sciences, and have in-depth experience in the design, execution and publication of research relevant to toxicology and human health. Trainees’ research activities are focused on hypothesis-driven studies of the mechanisms of action of environmental toxicants, including natural and man-made products. Emphasis is on understanding the links between the environment and health risks, the mode of action of toxicants and disease pathogenesis, and how emerging knowledge could be translated into prevention strategies, new therapeutic interventions and an improved scientific base for risk assessment. Graduates of this program have found jobs in academia, industry, government laboratories and regulatory agencies, as well as contract, consulting, and private research organizations.

The Curriculum in Toxicology is a multidisciplinary program, drawing on expertise from the faculty in the Schools of Medicine, Pharmacy, and Public Health and from accomplished scientists at research institutions in the area, including the Environmental Protection Agency and the National Institute of Environmental Health Sciences. The diversity of research opportunities offered by the Curriculum in Toxicology members is a unique strength. Research advisers are highly collaborative, serving as role models for the evolving paradigm of multidisciplinary research.

Toxicology Training Areas

Toxicology is a multidisciplinary field of study that integrates chemistry, biochemistry, biology, medical and environmental sciences toward understanding and preventing “the adverse effects of chemical, physical, or biological agents on people, animals, and the environment” (htpp://www.toxicology.org/). The main training areas in the Curriculum in Toxicology include organ-centric research foci (cardiopulmonary, developmental, hepatic, immunological, and neurological toxicology), as well as broader investigative domains, such as computational toxicology, molecular carcinogenesis, xenobiotic metabolism, systems toxicology, animal models of human disease, biomarkers of exposure and/or biological effects, with added emphasis in translating new knowledge into the prevention or treatment of human disease.